![]() ![]() ![]() For cancer related genes, Nav3, Cenpf, Muc5Ac, Mpp7, Gas1, MageD2, Dusp1, Ros, Polr2a, Rragd, Ros1, and Hoxa9 are mutated. Other frequently mutated genes in breast cancer, including Brca1 and Brca2, are not mutated. Results: We found Trp53 (Tp53) and Pik3g to be mutated. Here, we present an integrated map of the genome, transcriptome, and immunome of 4T1. The 4T1 murine mammary cancer cell line is one of the most widely used breast cancer models. 4HI-TRON - Helmholtz-Institut für Translationale Onkologie Mainz, Mainz, Germanyīackground: Tumor models are critical for our understanding of cancer and the development of cancer therapeutics.2University Medical Center of the Johannes Gutenberg, University Mainz, Mainz, Germany.1TRON gGmbH - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Universität Mainz Gemeinnützige GmbH, Mainz, Germany.Tadmor 1, Mathias Vormehr 2,3, Ugur Sahin 1,4 and Martin Löwer 1 * Barbara Schrörs 1, Sebastian Boegel 2, Christian Albrecht 1, Thomas Bukur 1, Valesca Bukur 1, Christoph Holtsträter 1, Christoph Ritzel 2, Katja Manninen 1, Arbel D. ![]()
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